Publications

2022

Rhea Nadkarni1,#, Wern Cui Chu1,#, Cheryl Lee1,#, Yasir Mohamud2, Lynn Yap1, Gee Ann Toh3, Sheryl Beh1, Radiance Lim1, Yiyun Michelle Fan2, Yizhuo Lyanne Zhang2, Kim Robinson4, Karl Tryggvason1, Honglin Luo2, Franklin Zhong3,4,*, Lena Ho1,5,*

Viral Proteases Activate the CARD8 Inflammasome in the Human Cardiovascular System. Journal of Experimental Medicine in press

Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L.

Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Cell Rep. 2022 Aug 16;40(7):111204.

Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL.

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome. Science. 2022 Jul 15;377(6603):328-335.

Chothani SP, Adami E, Widjaja AA, Langley SR, Viswanathan S, Pua CJ, Zhihao NT, Harmston N, D'Agostino G, Whiffin N, Mao W, Ouyang JF, Lim WW, Lim S, Lee CQE, Grubman A, Chen J, Kovalik JP, Tryggvason K, Polo JM, Ho L, Cook SA, Rackham OJL, Schafer S.

A high-resolution map of human RNA translation. Mol Cell. 2022 Aug 4;82(15):2885-2899.e8. doi: 10.1016/j.molcel.2022.06.023.

Kerouanton B, Schäfer S, Ho L, Chothani S, Rackham OJL. CLIPreg: Constructing translational regulatory networks from CLIP-, Ribo- and RNA-seq. Bioinformatics. 2022 Jun 2:btac363. doi: 10.1093/bioinformatics/btac363.

2021

Hui Hui Wong,Sze Hwee Seet ,Michael Maier ,..,Ajay S. Mathuru , Lena Ho#, Frederic A. Bard#, Bruno Reversade#

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy

American Journal of Human Genetics (2021) May 25, DOI: https://doi.org/10.1016/j.ajhg.2021.05.003

#equal contribution

C. Q. E. Lee, B. Kerouanton, S. Chothani, S. Zhang, Y. Chen, C. K. Mantri, D. H. Hock, R. Lim, R. Nadkarni, V. T. Huynh, D. Lim, W. L. Chew, F. L. Zhong, D. A. Stroud, S. Schafer, V. Tergaonkar, A. L. St John, O. J. L. Rackham, Ho L

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Nat. Commun. 12, 2130 (2021).

2020

Zhang, S., Reljić B, Liang, C., Kerouanton, B.,...,Stroud DA, Ho, L

Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.

Nature Communications (2020) 11:1312 | https://doi.org/10.1038/s41467-020-14999-2 Full text here

Chen Y, Ho L, Tergaonkar V.

sORF-Encoded MicroPeptides: New players in inflammation, metabolism, and precision medicine.

Cancer Lett. 2020 Nov 4:S0304-3835(20)30572-3. doi: 10.1016/j.canlet.2020.10.038.

Tan EE, Hopkins RA, Lim CK, Jamuar SS, Ong C, Thoon KC, Koh MJ, Shin EM, Lian DW, Weerasooriya M, Lee CZ, Soetedjo AAP, Lim CS, Au VB, Chua E, Lee HY, Jones LA, James SS, Kaliaperumal N, Kwok J, Tan ES, Thomas B, Wu LX, Ho L, Fairhurst AM, Ginhoux F, Teo AK, Zhang YL, Ong KH, Yu W, Venkatesh B, Tergaonkar V, Reversade B, Chin KC, Tan AM, Liew WK, Connolly JE. Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency. J Clin Invest. 2020 Nov 2;130(11):5817-5832. doi: 10.1172/JCI98882. PMID: 32750042;

2017

Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K.

Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.

Dev Cell. 2017 Sep 25;42(6):655-666.e3

Ho L,* van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B*.

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

Science. 2017 Aug 18;357(6352):707-713.

*Corresponding authors

Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K.

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

Cardiovasc Res. 2017 Jun 1;113(7):760-769

2015 and before

Ho L*, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Sczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B*.

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Cell Stem Cell. 2015 Oct 1;17(4):435-47

*Corresponding authors

Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG

Brg1 modulates enhancer activation in mesoderm lineage commitment

Development. 2015 Apr 15;142(8):1418-30

Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, Wilhelm B, Crabtree G, Sauvageau G, Thibault P, Lessard J.

An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation.

Exp Hematol. 2014 Aug; 42(8 Suppl):S4

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA.

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

Blood. 2014 Mar 13;123(11):1720-8

Ho L*, Chng SC*, Tian J, Reversade B.

ELABELA: a hormone essential for heart development signals via the apelin receptor.

Dev Cell. 2013 Dec 23;27(6):672-80.

*Equal Contribution

Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR.

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Nat Genetics. 2013 Jun;45(6):592-601

Ho L, Ronan JL, Miller EL, Ho W, Jothi R, Crabtree GR

esBAF Facilitates Pluripotency by Conditioning the Genome for LIF/STAT3 Signaling and by Regulating Polycomb Function

Nature Cell Biology. 2011 Jul 24;13(8):903-13

Ho L, Crabtree GR.

Chromatin Remodeling in Development

Nature. 2010 Jan 28; 463(7280):474-84.

Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP.

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Nature. 2010 Sep 16; 467(7313):338-42.

Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR.

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

Proceedings of the National Academy of Sciences USA. 2009 Mar 31;106(13):5181-6.

Ho L, Jothi R, Ronan JL, Cui K, Zhao K, Crabtree GR.

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.

Proceedings of the National Academy of Sciences USA. 2009 Mar 31;106(13):5187-91.

Gallo EM, Ho L, Winslow MM, Staton TL, Crabtree GR.

Selective role of calcineurin in haematopoiesis and lymphopoiesis.

EMBO Rep. 2008 Nov;9(11):1141-8.

Nguyen VH, Shashidhar S, Chang DS, Ho L, Kambham N, Bachmann M, Brown JM, Negrin RS.

The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation.

Blood. 2008 Jan 15;111(2):945-53.

Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR.

Calcineurin sets the bandwidth for discrimination of signals during thymocyte development.

Nature. 2007 Nov 29;450(7170):731-5.